Bremelanotide: A Treatment for Hypoactive Sexual Desire
doi: 10.1016/j.sxmr.2020.05.001 3 16% of women in the U.S. ages 21-60 are distressed from experiencing no or low sexual arousal, according to market research, and are actively seeking treatment. Ad Hoc Market Research: FSAD Prevalence Report (Oct 2015) conducted for SST LLC and based on US Census projections for 2016. 4 Thurman AR, Johnson I, Cornell KA, Hatheway J, Kim NN, Parish SJ, Dart C, Friend DR, Goldstein A. Safety of topical sildenafil cream, 3.6% in a randomized, placebo-controlled trial for the treatment of female sexual arousal disorder.
Ready to see why DARE to PLAY could be the best you've ever had?
Prior to the Phase 2b clinical study, DARE to PLAY was also tested in a preclinical study to assess its effects on the oral mucosa. These tests showed that daily exposure for 28 days did not cause irritation inside the mouth. The DARE to PLAY formulation does contain a proprietary combination of salts that support the absorption of sildenafil into the tissue. As a result, you may notice a mildly salty taste. DARE to PLAY can be used in both situations!
What do females use instead of Viagra?
In the Phase 2b clinical study, about 20% of sexual events were solo, and women reported that these experiences were often more satisfying than partnered events. Partnered events sometimes occurred under less-than-ideal conditions, like limited time or distractions, which can affect pleasure. DARE to PLAY is designed to complement, not replace, other approaches. It is a pharmacologic option focused on improving genital blood flow and physical responsiveness. Women often benefit most from a multimodal approach. 2024;21(9):793-799. doi:10.1093/jsxmed/qdae089 5 Goldstein S, Kukkonen T, Monsef A, Goldstein I. A double-blind, placebo-controlled, 2-way crossover study using thermography to assess the pharmacodynamics of sildenafil cream, 3.6% in healthy women.
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doi:10.1016/j.jsxm.2019.11.194 6 Johnson I, Thurman AR, Cornell KA, Hatheway J, Dart C, Brainard CP, Friend DR, Goldstein A. Preliminary efficacy of topical sildenafil cream for the treatment of female sexual arousal disorder: A randomized, placebo‑controlled, Phase 2b trial.
HOW IT WORKS
After registering, you will be asked, “Have you seen a provider already?” Select “No” to initiate a telehealth consultation. You’ll then be asked to: Provide your address informationSign the telehealth consent agreementFill out the telehealth questionnaireVerify your identification (by uploading a photo ID) Verify your identification (by uploading a photo ID) Within approximately 24 hours, your telehealth questionnaire responses will be reviewed by a licensed healthcare provider, and if medically appropriate, you will receive a prescription for DARE to PLAY. You can check the status of your prescription under “My Prescriptions” in the DARE Health Hub. You will be notified in the coming months, via email and text message, when ordering becomes available in your state. Ordering details will be added once available!
Though you cannot place an order quite yet...
Talk to your healthcare provider about DARE to PLAY. Bring the prescribing guide with you to your appointment. If your provider feels DARE to PLAY is medically appropriate for you, they will submit your prescription directly to the DARE Health Hub. You will then receive a phone call from the DARE Health Hub confirming receipt of your prescription and inviting you to register for an account. After registering, you’ll receive timely updates and a notification as soon as your prescription is ready to be ordered through the DARE Health Hub in the coming months. Impact of age, race, and medication use on efficacy endpoints in a randomized controlled trial of topical sildenafil cream for the treatment of female sexual arousal disorder.
Find out if treatment is right for you.
DARE to PLAY is designed to improve physical arousal by increasing genital blood flow. Many women find that enhancing physical responsiveness can also help restore desire and confidence. In the Phase 2b clinical study, women with low desire due to diminished physical arousal sensations experienced improved desire following use of DARE to PLAY. If low desire is influenced by emotional or relationship factors, combining DARE to PLAY with other approaches—like counseling or therapy—may provide the best results. Yes, please see these instructions for how to get a prescription.
Side effects
Anyone who is licensed to write prescriptions can prescribe it—including your primary care provider (PCP), family medicine doctor, OB/GYN, nurse practitioner, physician assistant, or another qualified specialist. The DARE Health Hub (powered by Medvantx) is a nationwide pharmacy and telehealth service. Whether you use the DARE Health Hub telehealth offering to get your prescription or get a prescription from your provider, this is where you will order/fill your prescription. This service offers contact-free ordering and discreet delivery directly to your doorstep. Here’s what buy generic viagra online you can expect depending on your preferred method of obtaining a prescription: Register for an account at the DARE Health Hub. Comparisons and correlations of 1‑month recall vs 24‑hour recall in patient‑reported outcomes of an exploratory, phase 2b, randomized, double‑blind, placebo‑controlled clinical trial of sildenafil cream, 3.6% for the treatment of female sexual arousal disorder. Symptoms and associated impact in pre‑ and postmenopausal women with sexual arousal disorder: a concept elicitation study.
- Vaginal moisturizers (e.g., Replens) provide long-lasting relief from dryness.
- Vaginal lubricants (e.g., Sylk, YES) reduce friction and discomfort during intercourse.
- Topical estrogen creams (e.g., Vagifem) locally treat vaginal atrophy and dryness.
- Pelvic floor physical therapy can improve muscle tone and blood flow to the pelvis.
- Sex therapy focuses on improving intimacy and communication with a partner.
- Mindfulness and sensate focus exercises can help reduce performance anxiety.
- Devices like the Eros-Clitoral Therapy Device use gentle suction to increase blood flow.
A New Topical Drug Delivery Platform: The Examples of Sildenafil and Ibuprofen. 11 American College of Obstetricians and Gynecologists. Preliminary efficacy of topical sildenafil cream for the treatment of female sexual arousal disorder [podcast episode].
| Medication | Legal Status | Date of Approval | Prescription Needed | OTC Availability | Notes |
|---|---|---|---|---|---|
| Flibanserin | Prescription | 2021 | Yes | No | Only for specific conditions |
| Bremelanotide | Research Use Only | N/A | No | No | Not approved for general use |
| Sildenafil | Off-label use | N/A | Yes | No | Used for sexual dysfunction |
The Green Room: A Podcast from Obstetrics & Gynecology. This product has not been reviewed by FDA for safety or efficacy.
- DHEA (Prasterone) is a hormonal precursor available as a vaginal insert for dyspareunia.
- ArginMax is an over-the-counter supplement containing L-arginine, ginseng, and ginkgo.
- Zestra is a topical arousal oil marketed to enhance sensation and blood flow.
- Fertility herbal blends often claim to boost libido but lack robust scientific evidence.
- Maca root is a popular Peruvian supplement sometimes used for hormonal balance.
- It's crucial to consult a doctor before using supplements due to potential side effects.
- The MHRA regulates supplements in the UK, but they are not held to drug efficacy standards.
DARE to PLAY Sildenafil Cream is manufactured in a 503B outsourcing facility under pharmaceutical Good Manufacturing Practices (GMP). She Can Health offers a low libido treatment that can stimulate blood flow to the intimate region.
Where the Magic Happens
DARE to PLAY has been studied in both pre-and postmenopausal women to evaluate safety, tolerability, and how the drug is absorbed in the body (pharmacokinetics). In these studies, the cream was well tolerated. The Phase 2b clinical study enrolled healthy pre-and perimenopausal women aged 18 to 45 who had a diagnosis of Female Sexual Arousal Disorder (FSAD). Similar to FDA-approved products for Hypoactive Sexual Desire Disorder (HSDD), FSAD trials conducted for FDA review typically focus on either pre-or postmenopausal populations. In the Phase 2b clinical study, approximately one-third of the participants were taking an SSRI.
What is FSAD?
An informal analysis compared women on SSRIs with those who were not and found that both groups showed positive trends in improved arousal sensations. Many vaginal products contain ingredients that can weaken condoms, increasing the risk of breakage. DARE to PLAY was tested using ASTM D7661-10, a standardized method that ensures a product is safe to use with condoms. Based on these tests, DARE to PLAY is compatible with all male condoms except those made of polyurethane. In the Phase 2b clinical study, women were allowed to use DARE to PLAY during oral sex, and it was well tolerated with no significant safety concerns. This treatment can help with low libido, hypoactive sexual desire disorder (HSDD), sexual dysfunction, and arousal disorder in women. When applied topically to the intimate area 30 mins before sexual activity, it may: Unlike other products on the market targeted to address Hypoactive Sexual Desire Disorder (HSDD), She Can Health's low libido treatment cream is made in the pharmacy with ingredients that can relax blood vessels, increase oxygenated blood flow, and heighten sensitivity to a woman's most sensitive parts. Each treatment is custom formulated for the individuals needs based on their treatment profile, if our prescriber deems the treatment is appropriate, the product will be produced in our London based compound pharmacy.
- Filbanserin can cause dizziness, sleepiness, nausea, and low blood pressure.
- It has serious interactions with alcohol and certain medications like antifungals.
- Bremelanotide side effects include nausea, vomiting, and temporary skin darkening.
- Ospemifene may increase the risk of blood clots and cause hot flashes.
- Testosterone therapy can cause acne, unwanted hair growth, and voice changes.
- Topical estrogen has minimal systemic absorption but can cause local irritation.
- All prescription treatments require a careful risk-benefit analysis with a doctor.
Our treatment for low libido is applied topically to the clitoris thirty minutes prior to anticipated activity.
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Two, we don’t want to assume that you will use DARE to PLAY a certain number of times per month. We will offer an option to auto-refill your prescription at a cadence that’s right for you, but we want to support and honor your choices and what feels right in your body, so whether one tube of DARE to PLAY lasts 10 days or one year–we think that’s perfect! Sign up to receive updates about DARE to PLAY and to be notified when it launches in your state. Diagnostic and Statistical Manual of viagra red Mental Disorders. The evolution of the female sexual disorder/dysfunction definitions, nomenclature, and classifications: a review of DSM, ICSM, ISSWSH, and ICD. Each treatment contains 15 ml of product (a month's supply) which is easily transportable for use whenever necessary. She Can Health's low libido treatment can help with low libido, sexual dysfunction, and arousal disorder in women.
The Sexy Science Behind Dare to Play
Compounded medications like DARE to PLAY are typically not covered by insurance. However, many people are able to use FSA or HSA funds to pay for it. DARE to PLAY Sildenafil Cream will cost about $10 per sexual experience — less than your favorite coffee run, and way more satisfying. One, we’re not a telehealth company trying to make more money by pushing products on women that they don’t need. We develop real, differentiated solutions for women who want and need them. When applied topically to the intimate area 30 mins before sexual activity it may: Unlike other products on the market to address Hypoactive Sexual Desire Disorder (HSDD), She Can Health's low libido treatment cream is made with pharmaceutical ingredients that may relax blood vessels, increase oxygenated blood flow, and heighten sensitivity to a women's most sensitive parts. Each treatment is custom formulated for the individual's needs based on the patient profile, if our prescriber deems the treatment as appropriate. Our low libido treatment cream is applied topically to the clitoris thirty minutes prior to anticipated sexual activity.
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